Improvement of Acid Stability of Lansoprazole by Co crystallization Techniques

American Journal of PharmTech Research

article

Raju Thenge¹  Laxmikant Mehesare¹  Vaibhao Adhao¹  inayak Shrikhande¹  Nilesh Mahajan² 

[1]Dr. Rajendra Gode College of Pharmacy

[2]Dadasaheb Balpande College of Pharmacy

关键词: Cocrystals;    Lansoprazole;    Acid stability;    FTIR;    Differential Scanning Calorimetry;   

DOI  :  10.46624/ajptr.2021.v11.i1.008

学科分类：药学

来源: American Journal Of Pharmtech Research

【 摘 要 】

The proton pump inhibitor are rapidly degraded in the acidic medium Thus it has less bioavailability since it is acid labile , mostly available in the enteric coated tablet to prevent acids degradation .But the onset of action is delayed. It is a great challenge to formulate simple compression solid dosage form of these drugs with considerable stability and efficacy. The Cocrystals of Lansoprazole was prepared by solvent evaporation using nicotinamide as a coformer. The prepared cocrystals were characterized by FTIR, SEM, DSC and XRD study. The cocrystals also evaluated for solubility and acid stability studies. The formation of Lansoprazole cocrystals were confirmed using FTIR, DSC showed the decreased in the melting point of cocrystals corresponds to melting point of pure Lansoprazole. The SEM also confirmed the changes in the habit of crystals. The acid stability study performed using HPLC and confirmed that the Cocrystals of Lansoprazole stable upto 75 % than the pure lansoprazole in 0.1 N HCL.

【 授权许可】

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