Cancer stem cell markers for liver cancer and pancreatic cancer

Stem cell research

article

Pu Xia¹  Da-Hua Liu¹ 

[1] Biological Anthropology Institute, College of Basic Medical Science, Liaoning Medical University

关键词: Cancer stem cell;    Liver cancer;    Pancreatic cancer;    Markers;    Tumorigenicity;   

DOI  :  10.1016/j.scr.2022.102701

学科分类：生理学

来源: Academic Press

【 摘 要 】

Cancer stem cells (CSC) theory has ushered in a new era of cancer research. Tumor recurrence, metastasis and chemotherapy resistance are all related to the existence of cancer stem cells. Further understanding of tumor heterogeneity will contribute to targeted treatment. Liver cancer and pancreatic cancer are common digestive gland tumors with high lethality . This article reviews the identification and isolation of CSC markers in hepatocellular carcinoma and pancreatic cancer. The markers related signal pathways are involved in the occurrence and development of tumors, and have a significant impact on the proliferation, metastasis and invasion of cancer cells , which can be used as potential molecular therapeutic targets. This study will be helpful to understand cancer stem cell like cells.

【 授权许可】

CC BY|CC BY-NC-ND