The evolving concept of liver cancer stem cells

Molecular Cancer

Review

Taro Yamashita¹  Shuichi Kaneko¹  Kouki Nio² 

[1] Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-Machi, 920-8641, Kanazawa, Ishikawa, Japan;Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Marsico Hall 5229 M, 125 Mason Farm Rd, 27599, Chapel Hill, NC, USA;Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-Machi, 920-8641, Kanazawa, Ishikawa, Japan;

关键词: Liver cancer;    Cancer stem cell;    Niche;    Chemoresistance;   

DOI  :  10.1186/s12943-016-0572-9

 received in 2016-10-14, accepted in 2016-12-19,  发布年份 2017

来源: Springer

【 摘 要 】

Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to the presence of cancer stem cells (CSCs). In the past few decades, CSCs have been identified and characterized in many tumors including liver cancer. Accumulated evidence has revealed many aspects of the biological behavior of liver CSCs and the mechanism of their regulation. Based on these findings, a number of studies have investigated eradication of liver CSCs. This review focuses on the recent advances in our understanding of the biology of liver CSCs and the development of strategies for their treatment.

【 授权许可】

CC BY   
© The Author(s). 2017