Evaluation of substance P and bradykinin levels in nasal secretions of patients with nasal polyposis with and without sensitivity to non-steroidal anti-inflammatory drugs

Laryngoscope Investigative Otolaryngology

article

Aleksandar Perić MD, PhD¹  Svjetlana Matković MD, PhD¹  Aleksandra Barać MD, PhD³  Tijana Vukadinović MD¹  Ljiljana Čvorović MD, PhD⁵  Danilo Vojvodić MD, PhD⁶ 

[1] Department of Otorhinolaryngology, Faculty of Medicine of the Military Medical Academy, University of Defence;ENT Department, Lovisenberg Diakonale Hospital;Clinical Center of Serbia, Clinic for Infectious and Tropical Diseases, School of Medicine, University in Belgrade;Department of Otorhinolaryngology, Clinical Center of Montenegro;Clinical Center of Serbia, Clinic for Otorhinolaryngology and Maxillofacial Surgery, School of Medicine, University in Belgrade;Institute for Medical Research, Division of Clinical and Experimental Immunology, Military Medical Academy Faculty of Medicine, University of Defence

关键词: aspirin;    bradykinin;    hypersensitivity;    nasal polyps;    neurogenic inflammation;    sinusitis;    substance P;   

DOI  :  10.1002/lio2.851

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Objective The role of neurogenic inflammation in pathogenesis of chronic rhinitis is well known. However, very little is known about its importance in pathogenesis of nasal polyposis (NP), especially in form of NP which appears as a part of aspirin-exacerbated respiratory disease (AERD). The aim of this study was to examine the concentrations of neuropeptides substance P (SP) and bradykinin (BK) in nasal secretions of patients with NP. Methods Fourteen patients with NP as a part of AERD with mild persistent asthma, 14 patients with NP without aspirin sensitivity, and 14 control subjects without nasal inflammation (C) entered this cross-sectional study. Clinical parameters (symptoms, endoscopic, and radiological findings) were assessed. The concentrations of SP and BK were measured in the nasal secretion samples using commercial human enzyme immunoassay kits. Results The concentration of SP in nasal secretions was significantly higher in NP patients without aspirin sensitivity and AERD patients compared to controls ( p  = .022; p  < .0001, respectively), but higher in AERD than in non-AERD patients ( p  = .018). The level of BK in nasal fluid was higher in non-AERD and AERD NP patients than in controls ( p  < .0001; p  < .0001, respectively), but also higher in AERD than in non-AERD patients ( p  < .0001). We found high positive correlations between BK in nasal fluid and Lund–Mackay computed tomography (CT) score in both non-AERD and AERD groups of NP patients. Conclusion Our results suggest more intense release of SP and BK from the nasal mucosa in patients with AERD than in patients with NP who do not have aspirin sensitivity. The strong correlation between concentration of BK in nasal secretions and CT score suggests that BK in nasal fluid could be used as a marker for disease severity as measured by the Lund–Mackay score.

【 授权许可】

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