Artemisinin attenuates IgM xenoantibody production via inhibition of T cell-independent marginal zone B cell proliferation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Lihua Liu¹  Juanzhi Zhao²  An Li¹  Xuan Yang¹  Ben Sprangers³  Shengqiao Li¹ 

[1] Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen;Department of Pharmacy, The Fifth Affiliated Hospital, University of Sun Yat-sen;Department of Microbiology and Immunology, Laboratory of Molecular Immunology ,(Rega institute);Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, University of Sun Yat-sen

关键词: humoral immunity;    IL-10;    immunization;    marginal zone;    murine model;    regulatory B cells;   

DOI  :  10.1002/JLB.4MA0520-717RRR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Artemisinin (ART) has been shown to suppress B cell activation and plasma cell formation. However, its effect on splenic marginal zone (MZ) B cells is unknown. Splenic MZ B cells play a critical role in rapidly induced Ab production against blood-borne foreign Ags. Dysfunction of MZ B cells, due to inhibition of its proliferation or displacement of its homing, results in an attenuated adaptive humoral response. Here, we investigate the effect of ART on splenic MZ B (CD19 + CD21 high CD23 low ) and B10 (CD19 + CD1d high CD5 + ) B cells to explore the mechanisms of ART-induced immunosuppression in T cell-deficient nude mice challenged with hamster xenoantigens. In this study, we demonstrate that ART decreases T cell-independent xenogeneic IgM Ab production and, this is associated with a strong suppression of MZ B cell proliferation and a relative increase of CD21 low CD23 + follicular and B10 B cells. In addition, this suppression impairs IL-10 production. Taken together, our data indicate that ART suppresses B cell immune responses through a distinctive effect on splenic MZ B and other B cells. This represents a new mechanism of ART-induced immunosuppression.

【 授权许可】

CC BY