Increasing complexity of NLRP3 inflammasome regulation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Julien Moretti¹  J. Magarian Blander¹ 

[1] The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Graduate School of Medical Science, Weill Cornell Medicine, Cornell University;Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Science, Weill Cornell Medicine, Cornell University;Joan and Sanford I. Weill Department of Medicine, Weill Cornell Graduate School of Medical Science, Weill Cornell Medicine, Cornell University;Sandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Science, Weill Cornell Medicine, Cornell University;Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Science, Weill Cornell Medicine, Cornell University

关键词: ASC;    caspase-11;    caspase-1;    IL-1;    inflammasome;    NLRP3;    phosphorylation;    ubiquitination;   

DOI  :  10.1002/JLB.3MR0520-104RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Inflammasomes are multiprotein complexes that assemble upon detection of danger signals to activate the inflammatory enzyme caspase-1, trigger secretion of the highly proinflammatory cytokine IL-1β, and induce an inflammatory cell death called pyroptosis. Distinctiveness of the nucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome resides in the diversity of molecules that induce its activation, indicating a certain intricacy. Furthermore, besides the canonical activation of NLRP3 in response to various stimuli, caspase-11-dependent detection of intracellular LPS activates NLRP3 through a noncanonical pathway. Several aspects of the NLRP3 inflammasome are not characterized or remain unclear. In this review, we summarize the different modes of NLRP3 activation. We describe recent insights into post-translational and cellular regulation that confer further complexity to NLRP3 inflammasomes.

【 授权许可】

CC BY