Notch signaling at the crossroads of innate and adaptive immunity

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Ashley Vanderbeck¹  Ivan Maillard¹ 

[1] Immunology Graduate Group, University of Pennsylvania;Veterinary Medical Scientist Training Program, University of Pennsylvania School of Veterinary Medicine;Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania;Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine

关键词: B cells;    dendritic cells;    hematopoietic stem cells;    innate lymphoid cells;    stromal cells;    T cells;   

DOI  :  10.1002/JLB.1RI0520-138R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Notch signaling is an evolutionarily conserved cell-to-cell signaling pathway that regulates cellular differentiation and function across multiple tissue types and developmental stages. In this review, we discuss our current understanding of Notch signaling in mammalian innate and adaptive immunity. The importance of Notch signaling is pervasive throughout the immune system, as it elicits lineage and context-dependent effects in a wide repertoire of cells. Although regulation of binary cell fate decisions encompasses many of the functions first ascribed to Notch in the immune system, recent advances in the field have refined and expanded our view of the Notch pathway beyond this initial concept. From establishing T cell identity in the thymus to regulating mature T cell function in the periphery, the Notch pathway is an essential, recurring signal for the T cell lineage. Among B cells, Notch signaling is required for the development and maintenance of marginal zone B cells in the spleen. Emerging roles for Notch signaling in innate and innate-like lineages such as classical dendritic cells and innate lymphoid cells are likewise coming into view. Lastly, we speculate on the molecular underpinnings that shape the activity and versatility of the Notch pathway.

【 授权许可】

CC BY