Shedding Light on the Role of Phosphorylation in Plant Autophagy

FEBS Letters

article

Hongbo Li¹  Yanglan Liao¹  Xuanang Zheng¹  Xiaohong Zhuang²  Caiji Gao¹  Jun Zhou³ 

[1] Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University;Centre for Cell and Developmental Biology, State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong;MOE & Guangdong Provincial Key Laboratory of Laser Life Science, Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal University

关键词: autophagy;    dephosphorylation;    phosphorylation;    post-translational modifications;    SnRK1;    TOR kinase;   

DOI  :  10.1002/1873-3468.14352

来源: John Wiley & Sons Ltd.

【 摘 要 】

Autophagy is a highly conserved quality control process that maintains cellular health by eliminating deleterious cargoes. Compared with the extensive studies in yeast and mammalian models, the molecular details and significance of post-translational modifications (PTMs) in the autophagy process in plants remain less well defined. In this review, we discuss recent progress in our understanding of phosphorylation, one of the most extensively studied PTMs, in the regulation of autophagosome biogenesis and autophagic degradation in plants. Based on the plant mass spectrometric database, we summarize the experimentally verified phosphorylation sites of the core autophagy machinery in plants. Furthermore, we put forward several approaches to test the roles of phosphorylation in the regulation of plant autophagy.

【 授权许可】

Unknown