Protein Tyrosine Phosphatases in Neuroblastoma: Emerging Roles as Biomarkers and Therapeutic Targets

Frontiers in Cell and Developmental Biology

Leire Torices¹  Maite Emaldi¹  José I. López²  Lorena Mosteiro²  Laura Zaldumbide²  Pablo Aguirre³  Caroline E. Nunes-Xavier⁴  Rafael Pulido⁵  Ricardo López-Almaraz⁶  Nagore García de Andoin⁷ 

[1] Biomarkers in Cancer Unit, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain;Department of Pathology, Cruces University Hospital, Barakaldo, Spain;Department of Pathology, Donostia University Hospital, San Sebastian, Spain;Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway;IKERBASQUE, Basque Foundation for Science, Bilbao, Spain;Pediatric Oncology and Hematology, Cruces University Hospital, Barakaldo, Spain;Unit of Pediatric Oncohematology, Donostia University Hospital, San Sebastian, Spain;

关键词: protein tyrosine phosphatases;    neuroblastoma;    biomarker;    cell signaling;    phosphorylation;    dephosphorylation;   

DOI  :  10.3389/fcell.2021.811297

来源: DOAJ

【 摘 要 】

Neuroblastoma is a type of cancer intimately related with early development and differentiation of neuroendocrine cells, and constitutes one of the pediatric cancers with higher incidence and mortality. Protein tyrosine phosphatases (PTPs) are key regulators of cell growth and differentiation by their direct effect on tyrosine dephosphorylation of specific protein substrates, exerting major functions in the modulation of intracellular signaling during neuron development in response to external cues driving cell proliferation, survival, and differentiation. We review here the current knowledge on the role of PTPs in neuroblastoma cell growth, survival, and differentiation. The potential of PTPs as biomarkers and molecular targets for inhibition in neuroblastoma therapies is discussed.

【 授权许可】

Unknown