The possible effects of the Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 on the practice of fertility preservation in female cancer patients in Japan

Reproductive medicine and biology

article

Chisato Kunitomi¹  Miyuki Harada¹  Yuko Sanada¹  Akari Kusamoto¹  Yasushi Takai²  Tatsuro Furui³  Yuko Kitagawa⁴  Mitsutoshi Yamada⁵  Chie Watanabe⁶  Koichiro Tsugawa⁷  Hiroyuki Nishiyama⁸  Hajime Hosoi⁹  Mitsuru Miyachi^1,10  Kazuhiko Sugiyama^1,11  Yoshinobu Maeda^1,12  Akira Kawai^1,13  Toshio Hamatani⁵  Keishi Fujio^1,14  Nao Suzuki^1,15  Yutaka Osuga¹ 

[1]Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo

[2]Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University

[3]Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine

[4]Department of Surgery, Keio University School of Medicine

[5]Department of Obstetrics and Gynecology, Keio University School of Medicine

[6]Department of Nursing, School of Nursing and Rehabilitation Sciences, Showa University

[7]Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine

[8]Department of Urology, Faculty of Medicine, University of Tsukuba

[9]Department of Nursing, Doshisha Women's College of Liberal Arts

[10]Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine

[11]Department of Clinical Oncology & Neuro-oncology Program, Hiroshima University Hospital

[12]Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

[13]Department of Musculoskeletal Oncology and Rehabilitation Medicine, National Cancer Center Hospital

[14]Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo

[15]Department of Obstetrics and Gynecology, St. Marianna University School of Medicine

关键词: assisted reproductive technology;    breast cancer;    childhood;    adolescent;    and young adult (CAYA);    fertility preservation;    oncofertility;   

DOI  :  10.1002/rmb2.12453

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose In 2017, the first guidelines for fertility preservation in cancer patients were published in Japan. However, the impact of the guidelines remains unknown. Therefore, the authors conducted a nationwide survey on cryopreservation procedures in the period from shortly before to after publication of the guidelines (2016–2019) and compared the results with our previous survey (2011–2015). The authors also surveyed reproductive specialists’ awareness of the guidelines and implementation problems. Methods The authors sent a questionnaire to 618 assisted reproductive technology facilities certified by the Japanese Society of Obstetrics and Gynecology. Results The authors received responses from 395 institutions (63.8%). Among them, 144 institutions conducted cryopreservation for cancer patients (vs. 126 in 2011–2015) and performed 2537 embryo or oocyte and 178 ovarian tissue cryopreservation procedures (vs. 1085 and 122, respectively). Compared with the previous period, indications were more varied and protocols for controlled ovarian stimulation were more standardized. Reproductive specialists’ interest in oncofertility was high, but many reported three main difficulties: selecting a treatment method, storing samples in the long term, and securing the necessary human resources. Conclusions The practice of fertility preservation in cancer patients in Japan has been considerably affected by the first Japanese guidelines.

【 授权许可】

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