The Role of the Kynurenine Pathway in the (Patho) physiology of Maternal Pregnancy and Fetal Outcomes: A Systematic Review

International Journal of Tryptophan Research

article

Sofie KM van Zundert¹  Michelle Broekhuizen³  Ashley JP Smit¹  Lenie van Rossem¹  Mina Mirzaian²  Sten P Willemsen¹  AH Jan Danser⁴  Yolanda B De Rijke²  Irwin KM Reiss³  Daphne Merkus⁵  Régine PM Steegers-Theunissen¹ 

[1] Department of Obstetrics and Gynecology, Erasmus MC University Medical Center;Department of Clinical Chemistry, Erasmus MC University Medical Center;Division of Neonatology, Department of Pediatrics, Erasmus MC University Medical Center;Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC University Medical Center;Division of Experimental Cardiology, Department of Cardiology, Erasmus MC University Medical Center;Department of Biostatistics, Erasmus MC University Medical Center;Walter Brendel Center of Experimental Medicine, University Clinic Munich, Ludwig Maximillian University Munich

关键词: tryptophan;    pregnancy;    depression;    gestational diabetes mellitus;    preeclampsia;    pregnancy-induced hypertension;    fetal growth restriction;    preterm birth;    spontaneous abortion;   

DOI  :  10.1177/11786469221135545

学科分类：生理学与病理学

来源: Sage Journals

【 摘 要 】

Introduction: Tryptophan is the precursor of kynurenine pathway (KP) metabolites which regulate immune tolerance, energy metabolism, and vascular tone. Since these processes are important during pregnancy, changes in KP metabolite concentrations may play a role in the pathophysiology of pregnancy complications. We hypothesize that KP metabolites can serve as novel biomarkers and preventive therapeutic targets. This review aimed to provide more insight into associations between KP metabolite concentrations in maternal and fetal blood, and in the placenta, and adverse maternal pregnancy and fetal outcomes.

【 授权许可】

CC BY|CC BY-NC