Vaccines for COVID-19: Perspectives, Prospects, and Challenges Based on Candidate SARS, MERS, and Animal Coronavirus Vaccines

European Medical Journal Allergy & Immunology

article

Linda J. Saif¹ 

[1] Food Animal Health Research Program;Ohio Agricultural Research & Development Center;College of Food, Agricultural, and Environmental Sciences;Veterinary Preventive Medicine Department, College of Veterinary Medicine, The Ohio State University

关键词: Animal coronavirus;    coronavirus (CoV);    COVID-19;    Middle East respiratory syndrome (MERS);    passive immunotherapies;    severe acute respiratory syndrome (SARS);    vaccines.;   

DOI  :  10.33590/emj/200324

学科分类：社会科学、人文和艺术（综合）

来源: European Medical Journal

【 摘 要 】

Several coronaviruses (CoV) are widespread inhumans and cause only mild upper respiratoryinfections and colds; however, pandemicoutbreaks of more severe coronavirus infectionsin humans have become more prevalent. Thesevere acute respiratory syndrome (SARS)coronavirus (betaCoV Lineage B) causedthe first pandemic of the 21st century in2002–2003, with its epicentre in China. TheMiddle East respiratory syndrome (MERS)coronavirus (betaCoV Lineage C) emergedalmost a decade later and infections continue inthe Middle East. Now, only 7 years after MERS,the COVID-19 SARS-CoV-2 (betaCoV LineageB) has emerged, again in China, as an evenmore devastating pandemic. Its occurrencewas not unexpected, because like SARS, forwhich the host origin was bats, scientists hadpreviously identified SARS-like CoV in these animals in China.1 Based on sequence analysisof the SARS-CoV-2 genome, it is more closelyrelated to SARS (80%) and to one bat RaTG13SARS-like CoV (96%) than to MERS CoV (54%).

【 授权许可】

CC BY-NC