Doxycycline: From Ocular Rosacea to COVID-19 Anosmia. New Insight Into the Coronavirus Outbreak

Frontiers in Medicine

article

Chiara Bonzano¹  Davide Borroni²  Andrea Lancia³  Elisabetta Bonzano⁴ 

[1] Eye Clinic, University of Genoa and IRCCS San Martino Polyclinic Hospital;Cornea Unit, Royal Liverpool University Hospital, United Kingdom;Department of Radiation Oncology, IRCCS San Matteo Polyclinic Foundation;PhD School in Experimental Medicine, University of Pavia

关键词: COVID-19;    doxycycline;    coronavirus (CoV);    SARS;    CoV;    anosmia;   

DOI  :  10.3389/fmed.2020.00200

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Coronavirus Disease 19 (COVID-19) caused by Severe Acute Respiratory Syndrome-Coronavirus2 (SARS-CoV-2) it usually manifests with respiratory symptoms (1). Similarly, to other human respiratory Coronaviruses (HCoV), it seems to have a neuroinvasive and neurotropic activity (1, 2). In the retrospective case series study conducted by Mao et al. three categories of neurological symptoms COVID19-related included central nervous system (CNS) manifestations, peripheral nervous system (PNS) symptoms and musculoskeletal disorders (2). Hyposmia has been reported as a possible peripheral nervous system (PNS) symptom caused by COVID-19 infection (2). In our experience, the smell alteration (hyposmia, anosmia) seems to be one of the first manifestations of COVID-19 disease, with or without the loss of taste (dysgeusia). Sometimes it remains the only symptom; more often, it comes with fatigue, fever, and cough. We provide a commentary on how COVID-19 could affect the sense of smell and the reason why doxycycline (Dox) could play a role in its recover.

【 授权许可】

CC BY