期刊论文详细信息
Frontiers in Cardiovascular Medicine
The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease
article
Lotte Slenders1  Daniëlle E. Tessels1  Sander W. van der Laan1  Gerard Pasterkamp1  Michal Mokry1 
[1] Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht;Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht
关键词: scRNA-sequencing;    transcriptomics;    -omics;    single-cell;    atherosclerosis;   
DOI  :  10.3389/fcvm.2022.826103
学科分类:地球科学(综合)
来源: Frontiers
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【 摘 要 】

Atherosclerosis still is the primary cause of death worldwide. Our characterization of the atherosclerotic lesion is mainly rooted in definitions based on pathological descriptions. We often speak in absolutes regarding plaque phenotypes: vulnerable vs. stable plaques or plaque rupture vs. plaque erosion. By focusing on these concepts, we may have oversimplified the atherosclerotic disease and its mechanisms. The widely used definitions of pathology-based plaque phenotypes can be fine-tuned with observations made with various -omics techniques. Recent advancements in single-cell transcriptomics provide the opportunity to characterize the cellular composition of the atherosclerotic plaque. This additional layer of information facilitates the in-depth characterization of the atherosclerotic plaque. In this review, we discuss the impact that single-cell transcriptomics may exert on our current understanding of atherosclerosis.

【 授权许可】

CC BY   

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