Progress of Single-Cell RNA Sequencing Technology in Myocardial Infarction Research

Frontiers in Cardiovascular Medicine

article

Lanfang Li¹  Min Wang¹  Qiuxiao Ma¹  Yunxiu Li³  Jingxue Ye¹  Xiaobo Sun¹  Guibo Sun¹ 

[1] Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences;Xiyuan Hospital, China Academy of Chinese Medical Sciences;Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Centre, College of Integration Science, College of Pharmacy, Yanbian University

关键词: angiogenesis;    cardiomyocyte;    fibroblast;    single-cell RNA sequencing;    myocardial infarction;    immune cell;   

DOI  :  10.3389/fcvm.2022.768834

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

After myocardial infarction, the heart enters a remodeling and repair phase that involves myocardial cell damage, inflammatory response, fibroblast activation, and, ultimately, angiogenesis. In this process, the proportions and functions of cardiomyocytes, immune cells, fibroblasts, endothelial cells, and other cells change. Identification of the potential differences in gene expression among cell types and/or transcriptome heterogeneity among cells of the same type greatly contribute to understanding the cellular changes that occur in heart and disease conditions. Recent advent of the single-cell transcriptome sequencing technology has facilitated the exploration of single cell diversity as well as comprehensive elucidation of the natural history and molecular mechanisms of myocardial infarction. In this manner, novel putative therapeutic targets for myocardial infarction treatment may be detected and clinically applied.

【 授权许可】

CC BY