Review of Single-Cell RNA Sequencing in the Heart

International Journal of Molecular Sciences

Shintaro Yamada¹  Seitaro Nomura¹ 

[1] Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan;

关键词: single-cell RNA sequencing;    heart;    cardiomyocyte;    cardiovascular development;    cardiovascular disease;   

DOI  :  10.3390/ijms21218345

来源: DOAJ

【 摘 要 】

Single-cell RNA sequencing (scRNA-seq) technology is a powerful, rapidly developing tool for characterizing individual cells and elucidating biological mechanisms at the cellular level. Cardiovascular disease is one of the major causes of death worldwide and its precise pathology remains unclear. scRNA-seq has provided many novel insights into both healthy and pathological hearts. In this review, we summarize the various scRNA-seq platforms and describe the molecular mechanisms of cardiovascular development and disease revealed by scRNA-seq analysis. We then describe the latest technological advances in scRNA-seq. Finally, we discuss how to translate basic research into clinical medicine using scRNA-seq technology.

【 授权许可】

Unknown