Case Report: Importance of MRI Examination in the Diagnosis and Evaluation of COVID-19 mRNA Vaccination Induced Myocarditis: Our Experience and Literature Review

Frontiers in Cardiovascular Medicine

article

Keita Watanabe¹  Takashi Ashikaga¹  Yasuhiro Maejima²  Susumu Tao²  Mao Terui¹  Tetsuya Kishigami¹  Masakazu Kaneko¹  Ryota Nakajima¹  Shinichiro Okata¹  Tetsumin Lee¹  Tomoki Horie¹  Masashi Nagase¹  Giichi Nitta¹  Ryoichi Miyazaki¹  Sho Nagamine¹  Yasutoshi Nagata¹  Toshihiro Nozato¹  Masahiko Goya²  Tetsuo Sasano² 

[1] Department of Cardiology, Japanese Red Cross Musashino Hospital;Department of Cardiology, Tokyo Medical and Dental University

关键词: cardiac MRI;    COVID-19;    mRNA vaccination;    myocarditis;    case series;    review;    case report;   

DOI  :  10.3389/fcvm.2022.844626

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Acute myocarditis is a rare but serious complication associated with mRNA-based coronavirus disease 2019 (COVID-19) vaccination. In this article, four COVID-19 mRNA vaccination induced myocarditis cases managed at our tertiary Medical Center have been discussed. Three patients had typical myocarditis. One patient suffered from atrioventricular block and heart failure, which required more intensive treatment, but eventually improved. Additionally, a review of cardiac magnetic resonance imaging (MRI) features related to the diagnosis of myocarditis showed that COVID-19 mRNA vaccine-associated myocarditis tend to have more late-gadolinium enhancement (LGE) accumulation in the inferior lateral wall direction. According to a report by the U.S. Centers for Disease Control and Prevention (CDC), the diagnosis of COVID-19 mRNA vaccine-associated myocarditis is based on clinical symptoms, altered myocardial enzymes, cardiac MRI finding, or histopathology. Cardiac MRI is relatively less invasive than myocardial biopsy and plays an important role in the diagnosis of myocarditis. This review may aid in the diagnosis of COVID-19 mRNA vaccine-associated myocarditis.

【 授权许可】

CC BY