Case Report: Importance of MRI Examination in the Diagnosis and Evaluation of COVID-19 mRNA Vaccination Induced Myocarditis: Our Experience and Literature Review

Frontiers in Cardiovascular Medicine

Sho Nagamine¹  Mao Terui¹  Giichi Nitta¹  Shinichiro Okata¹  Masakazu Kaneko¹  Tetsuya Kishigami¹  Masashi Nagase¹  Takashi Ashikaga¹  Tomoki Horie¹  Ryoichi Miyazaki¹  Toshihiro Nozato¹  Tetsumin Lee¹  Yasutoshi Nagata¹  Ryota Nakajima¹  Tetsuo Sasano²  Yasuhiro Maejima²  Masahiko Goya²  Keita Watanabe²  Susumu Tao² 

[1] Department of Cardiology, Japanese Red Cross Musashino Hospital, Tokyo, Japan;Department of Cardiology, Tokyo Medical and Dental University, Tokyo, Japan;

关键词: cardiac MRI;    COVID-19;    mRNA vaccination;    myocarditis;    case series;    review;   

DOI  :  10.3389/fcvm.2022.844626

来源: DOAJ

【 摘 要 】

Acute myocarditis is a rare but serious complication associated with mRNA-based coronavirus disease 2019 (COVID-19) vaccination. In this article, four COVID-19 mRNA vaccination induced myocarditis cases managed at our tertiary Medical Center have been discussed. Three patients had typical myocarditis. One patient suffered from atrioventricular block and heart failure, which required more intensive treatment, but eventually improved. Additionally, a review of cardiac magnetic resonance imaging (MRI) features related to the diagnosis of myocarditis showed that COVID-19 mRNA vaccine-associated myocarditis tend to have more late-gadolinium enhancement (LGE) accumulation in the inferior lateral wall direction. According to a report by the U.S. Centers for Disease Control and Prevention (CDC), the diagnosis of COVID-19 mRNA vaccine-associated myocarditis is based on clinical symptoms, altered myocardial enzymes, cardiac MRI finding, or histopathology. Cardiac MRI is relatively less invasive than myocardial biopsy and plays an important role in the diagnosis of myocarditis. This review may aid in the diagnosis of COVID-19 mRNA vaccine-associated myocarditis.

【 授权许可】

Unknown