Contrast Sensitivity Deficits and Its Structural Correlates in Fuchs Uveitis Syndrome

Frontiers in Medicine

article

Fang-Yue Zhou¹  Yi-Sha Li¹  Xingneng Guo¹  Xiutong Shi²  Ke Wu¹  Jing-Wei Zheng¹  Xia-Xin Li¹  Jiaqing Wu¹  Ruru Liu¹  Ma-Li Dai¹  Xiu-Feng Huang³  Fang Hou¹  Dan Lin¹  Yu-Qin Wang¹ 

[1] School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University;School of Optometry, Tianjin Vocational Institute;The Second Affiliated Hospital, Wenzhou Medical University;Wenzhou Medical University-Monash BDI Alliance in Clinical and Experimental Biomedicine, Wenzhou Medical University

关键词: Fuchs uveitis syndrome;    contrast sensitivity;    qCSF;    grading of haze;    optical coherence tomography angiography;   

DOI  :  10.3389/fmed.2022.850435

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Purpose To investigate the deficits in contrast sensitivity in patients with Fuchs uveitis syndrome (FUS) and to explore the potential relationship between contrast sensitivity and ocular structure. Methods In this prospective study, 25 patients with FUS and 30 healthy volunteers were recruited. Eyes were divided into three groups: FUS-affected eyes (AE), fellow eyes (FE), and healthy eyes. The contrast sensitivity function (CSF) of all participants was evaluated using the quick CSF (qCSF) method. Fundus photographs were collected for the analysis of refractive media, and vascular density (VD) was assessed using optical coherence tomography angiography (OCTA). Data were analyzed and compared using the generalized estimating equation (GEE). Results The CSF of AE was significantly lower than that of FE and controls, while no significant difference was observed between FE and controls. Contrast sensitivity was negatively correlated with the grade of haze. No significant correlation was found between visual function and VDs in FUS eyes. Conclusions We found that the CSF of FUS-affected eyes was significantly reduced, and the visual impairment was predominantly caused by the refractive media turbidity.

【 授权许可】

CC BY