Contrast Sensitivity Is Associated With Chorioretinal Thickness and Vascular Density of Eyes in Simple Early-Stage High Myopia

Frontiers in Medicine

article

Xinting Liu¹  Yanli Wang¹  Xiaoxiao Ying²  Fen Zhang¹  Jing Huang¹  Hang Yu¹  Qian Wang¹  Miaoran Zheng¹  Fang Hou¹  Luis Lesmes³  Zhong-Lin Lu⁴  Fan Lu¹  Xinjie Mao¹ 

[1] School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University;Cixi People’s Hospital;Adaptive Sensory Technology, Inc.;Division of Arts and Sciences;Center for Neural Science, Department of Psychology, New York University;NYU-ECNU Institute of Brain and Cognitive Science

关键词: simple high myopia;    contrast sensitivity;    qCSF;    choroidal thickness;    retinal thickness and vascular density;   

DOI  :  10.3389/fmed.2022.847817

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective To evaluate the contrast sensitivity function (CSF), chorioretinal thickness and vascular density as well as their relationships in subjects with simple early-stage high myopia. Methods Eighty-one young subjects were enrolled in this study. They were categorized into the simple high myopia group (sHM, n = 51) and the low-moderate myopia group (control group, n = 30). Monocular CSF under best correction was measured with the qCSF method. Retinal superficial and deep vascular density, inner and outer retinal thickness and choroidal thickness were measured using optical coherence tomography angiography. Results The area under log CSF (AULCSF) and cutoff spatial frequency (Cutoff SF) of the sHM group were significantly reduced compared to those of the control group ( P = 0.003 and P < 0.001, respectively). The parafoveal and perifoveal retinal thickness, deep vascular density and choroidal thickness were also significantly reduced in the sHM group (all P < 0.05). Multiple regression analysis revealed that AULCSF was significantly correlated with retinal deep vascular density, outer retinal thickness in the parafoveal and perifoveal areas (all P < 0.05). Conclusion Compared to low to moderate myopic eyes, patients with simple high myopia have thinner retinal and choroidal thickness, lower retinal vascular density, and reduced contrast sensitivity. Moreover, the CSF was correlated with the measures of chorioretinal structure and vasculature. The results suggest that the CSF is a sensitive functional endpoint in simple early-stage high myopia.

【 授权许可】

CC BY