Contrast Sensitivity Deficits and Its Structural Correlates in Fuchs Uveitis Syndrome

Frontiers in Medicine

Xiutong Shi¹  Yi-Sha Li¹  Yu-Qin Wang¹  Jing-Wei Zheng¹  Ruru Liu¹  Fang Hou¹  Jiaqing Wu²  Xingneng Guo²  Ma-Li Dai²  Fang-Yue Zhou²  Dan Lin²  Ke Wu²  Xiu-Feng Huang²  Xia-Xin Li³ 

[1] Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China;;School of Ophthalmology &School of Optometry, Tianjin Vocational Institute, Tianjin, China;

关键词: Fuchs uveitis syndrome;    contrast sensitivity;    qCSF;    grading of haze;    optical coherence tomography angiography;   

DOI  :  10.3389/fmed.2022.850435

来源: DOAJ

【 摘 要 】

PurposeTo investigate the deficits in contrast sensitivity in patients with Fuchs uveitis syndrome (FUS) and to explore the potential relationship between contrast sensitivity and ocular structure.MethodsIn this prospective study, 25 patients with FUS and 30 healthy volunteers were recruited. Eyes were divided into three groups: FUS-affected eyes (AE), fellow eyes (FE), and healthy eyes. The contrast sensitivity function (CSF) of all participants was evaluated using the quick CSF (qCSF) method. Fundus photographs were collected for the analysis of refractive media, and vascular density (VD) was assessed using optical coherence tomography angiography (OCTA). Data were analyzed and compared using the generalized estimating equation (GEE).ResultsThe CSF of AE was significantly lower than that of FE and controls, while no significant difference was observed between FE and controls. Contrast sensitivity was negatively correlated with the grade of haze. No significant correlation was found between visual function and VDs in FUS eyes.ConclusionsWe found that the CSF of FUS-affected eyes was significantly reduced, and the visual impairment was predominantly caused by the refractive media turbidity.

【 授权许可】

Unknown