Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature

Frontiers in Medicine

article

Changhong Wei¹  Yili Ma³  Dengqiang Wu²  Xiaoyu Chen¹  Chunjun Li¹  Jun Chen¹  Sufang Zhou² 

[1] Department of Pathology, Guangxi Medical University Cancer Hospital;Guangxi Key Laboratory of Bio-Targeting Theranostics, National Center for International Research of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University;Department of Biochemistry and Molecular Biology, School of Pre-clinical Science, Guangxi Medical University

关键词: soft tissue sarcoma;    sclerosing epithelioid fibrosarcoma;    immunohistochemistry;    fish;    EWSR1;   

DOI  :  10.3389/fmed.2022.833864

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Sclerosing epithelioid fibrosarcoma (SEF) is a rare subtype of soft tissue tumors, and SEF originating from the side of the spine is even rarer. We report that a 28-year-old young woman suffered from chest pain and back pain for 3 years, and thereafter she went to see a doctor because her condition deteriorated. Enhanced CT showed that the right posterior upper chest wall mass invaded the adjacent bone, and the boundary between the lesion and the surrounding tissues was relatively clear. She then underwent posterior tumor removal surgery. The pathological examination confirmed the diagnosis of SEF. In histomorphology, the tumor displayed a typical epithelioid clear cell morphology, accompanied by extensive vitrification and fibrosis, which better helped to differentiate the tumor from low grade fibromyxoid sarcoma, solitary fibrous tumor and other entities. The immunohistochemical analysis showed a diffuse positive reaction to MUC4, a highly specific marker of SEF, which was detected by Immunohistochemistry (IHC), and fluorescence in-situ hybridization (FISH) confirmed that the EWSR1 gene was rearranged, while the FUS gene was not rearranged. This is the first time that we have encountered such this rare case and thus report this case with updated literature related to this tumor.

【 授权许可】

CC BY