High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas

Cancers

Patrick Groothuis¹  Wim Dokter¹  Fred Dijcks¹  Nicola Penel²  Antoine Italiano³  Nuria Kotecki⁴ 

[1] Byondis B.V., Microweg 22, 6503 GB Nijmegen, The Netherlands;Medical Oncology Department, Centre Oscar Lambret, 59000 Lille, France;Medical Oncology Department, Institut Bergonié, 33000 Bordeaux, France;Medical Oncology Department, Institut Jules Bordet, 1000 Brussels, Belgium;

关键词: soft tissue sarcoma;    5T4;    trophoblast glycoprotein;    immunohistochemistry;    cell surface antigen;   

DOI  :  10.3390/cancers13194841

来源: DOAJ

【 摘 要 】

The expression of 5T4/trophoblast glycoprotein was evaluated in several histological subtypes of soft tissue sarcoma (STS) to determine whether the prevalence and level of expression of this membrane-associated glycoprotein is sufficient for use in targeted therapies. Tumor tissue microarrays containing cores from different histological subtypes of STS were stained using a standardized immunohistochemical staining method to detect 5T4; the level of staining was assessed using a semi-quantitative scoring method. No 5T4 staining was seen in the angiosarcomas and liposarcomas investigated in this study. 5T4 staining in the other STS subtypes was seen in more than 50% of cases, warranting further investigation into whether this antigen could evoke an anti-tumor immune response or can be used as target for the delivery of more potent toxins through antibody drug conjugates.

【 授权许可】

Unknown