The Potential Therapeutic Applications of Olfactory Ensheathing Cells in Regenerative Medicine

Cell Transplantation

Review

Jia-Rong Fan¹  Cheng-You Lu¹  Woei-Cherng Shyu²  Ruey-Hwang Chou³  Yung-Luen Yu³ 

[1] Center for Neuropsychiatry and Translational Medicine Research Center, China Medical University and Hospital, Taichung, Taiwan;Center for Neuropsychiatry and Translational Medicine Research Center, China Medical University and Hospital, Taichung, Taiwan;Graduate Institute of Immunology, China Medical University, Taichung, Taiwan;Graduate Institute of Cancer Biology, Center for Molecular Medicine, China Medical University, Taichung, Taiwan;Department of Biotechnology, Asia University, Taichung, Taiwan;

关键词: Olfactory ensheathing cells (OECs);    Neuronal injury;    Regenerative medicine;   

DOI  :  10.3727/096368914X678508

 received in 2013-12-02, accepted in 2014-01-30,  发布年份 2014

来源: Sage Journals

【 摘 要 】

Olfactory ensheathing cells (OECs) are unique glia cells restricted to the primary olfactory system including the olfactory mucosa, olfactory nerve, and the outer nerve layer of the olfactory bulb. OECs guide growing olfactory axons from the neurons of the nasal cavity olfactory mucosa to the olfactory bulb to connect both the peripheral nervous system (PNS) and central nervous system (CNS). Based on these specialized abilities of OECs, transplantation of OECs to injury sites has been widely investigated for their potential therapeutic applications in neural repair in different injuries. In this article, we reviewed the properties of OECs and their roles in olfactory regeneration and in treatment of different injuries including spinal cord injury, PNS injury, and stroke and neurodegenerative diseases.

【 授权许可】

Unknown   
© 2014 Cognizant Comm. Corp.