Long-Term outcome of Olfactory Ensheathing Cell Transplantation in Six Patients with Chronic Complete Spinal Cord Injury

Cell Transplantation

Review

Yanxing Guo¹  Danna Cao¹  Ruofei Qiao¹  Chunxia Jia¹  Lei Yang¹  Hongxing Zhang¹  Ran Qi¹  Yaojian Rao¹  Zesheng Cui¹  Wenxiao Zhu¹  Yongjun Wang² 

[1] Department of Spine Surgery, Luoyang Orthopedic Hospital of Henan Province, Luoyang, P.R. China;Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China;

关键词: Olfactory ensheathing cells (OECs);    Cell transplantation;    Spinal cord injuries;    Clinical effect;    Safety;   

DOI  :  10.3727/096368913X672127

 received in 2012-12-26, accepted in 2013-08-20,  发布年份 2013

来源: Sage Journals

【 摘 要 】

The aim of the study was to analyze the clinical efficacy and safety of olfactory ensheathing cell (OEC) transplantation for treating patients with chronic, complete spinal cord injury (SCI). Six patients with six chronic complete spinal cord injuries were recruited and treated with autologous OEC transplantation and followed for 24 months. The scores from before and after transplantation were analyzed. This was a self-control experiment. There was significant amelioration in the scores of the standard neurological classification of spinal cord injury made by the America Spinal Cord Injury Association (ASIA) and the International Association of Neurorestoratology–Spinal Cord Injury Functional Rating Scale (IANR-SCIFRS) following OEC transplantation with 24 months of follow-up. No clinical complications were observed. OEC transplantation would appear to be clinically safe and may promote the neurofunctional recovery of SCI based on data from six patients. This manuscript is published as part of the International Association of Neurorestoratology (IANR) supplement issue of Cell Transplantation.

【 授权许可】

Unknown   
© 2013 Cognizant Comm. Corp.