Transplantation of Olfactory Ensheathing Cells as Adjunct Cell Therapy for Peripheral Nerve Injury

Cell Transplantation

Review

Konstantin Wewetzer¹  Peter M. Vogt²  Kerstin Reimers²  Christine Radtke² 

[1] Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany;Department of Functional and Applied Anatomy, Center of Anatomy, Hannover Medical School, Hannover, Germany;Center of Systems Neuroscience, Hannover, Germany;Department of Plastic, Hand- and Reconstructive Surgery, Hannover Medical School, Hannover, Germany;

关键词: Wallerian degeneration;    Cell transplantation;    Olfactory ensheathing cells (OECs);    Regeneration;    Remyelination;    Cell expansion;   

DOI  :  10.3727/096368910X522081

 received in 2010-02-15, accepted in 2010-06-25,  发布年份 2011

来源: Sage Journals

【 摘 要 】

Traumatic events, such as work place trauma or motor vehicle accident violence, result in a significant number of severe peripheral nerve lesions, including nerve crush and nerve disruption defects. Transplantation of myelin-forming cells, such as Schwann cells (SCs) or olfactory ensheathing cells (OECs), may be beneficial to the regenerative process because the applied cells could mediate neurotrophic and neuroprotective effects by secretion of chemokines. Moreover, myelin-forming cells are capable of bridging the repair site by establishing an environment permissive to axonal regeneration. The cell types that are subject to intense investigation include SCs and OECs either derived from the olfactory bulb or the olfactory mucosa, stromal cells from bone marrow (mesenchymal stem cells, MSCs), and adipose tissue-derived cells. OECs reside in the peripheral and central nervous system and have been suggested to display unique regenerative properties. However, so far OECs were mainly used in experimental studies to foster central regeneration and it was not until recently that their regeneration-promoting activity for the peripheral nervous system was recognized. In the present review, we summarize recent experimental evidence regarding the regenerative effects of OECs applied to the peripheral nervous system that may be relevant to design novel autologous cell transplantation therapies.

【 授权许可】

Unknown   
© 2011 Cognizant Comm. Corp.