A Brief Overview of the Paradoxical Role of Glucocorticoids in Breast Cancer

Breast Cancer: Basic and Clinical Research

Review

Ekaterina M Zhidkova¹  Marianna G Yakubovskaya¹  Alena V Savinkova¹  Evgeniya S Lylova¹  Gennady A Belitsky¹  Kirill I Kirsanov²  Ekaterina A Lesovaya³  Sergey A Mertsalov⁴ 

[1] Department of Oncology, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia;Department of Oncology, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia;Department of General Medical Practice, RUDN University, Moscow, Russia;Department of Oncology, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia;I.P. Pavlov Ryazan State Medical University, Ryazan, Russia;I.P. Pavlov Ryazan State Medical University, Ryazan, Russia;

关键词: Breast cancer;    glucocorticoid;    glucocorticoid receptor;    selective glucocorticoid receptor agonists (SEGRA);    REDD1;    breast cancer metastasis;   

DOI  :  10.1177/1178223420974667

 received in 2020-06-02, accepted in 2020-10-21,  发布年份 2020

来源: Sage Journals

【 摘 要 】

Glucocorticoids (GCs) are stress hormones that play multiple roles in the regulation of cancer cell differentiation, apoptosis, and proliferation. Some types of cancers, such as hematological malignancies, can be effectively treated by GCs, whereas the responses of epithelial cancers to GC treatment vary, even within cancer subtypes. In particular, GCs are frequently used as supporting treatment of breast cancer (BC) to protect against chemotherapy side effects. In the therapy of nonaggressive luminal subtypes of BC, GCs can have auxiliary antitumor effects due to their cytotoxic actions on cancer cells. However, GCs can promote BC progression, colonization of distant metastatic sites, and metastasis. The effects of GCs on cell proliferation vary with BC subtype and its molecular profile and are realized via the activation of glucocorticoid receptor (GR), a well-known transcriptional factor involved in the regulation of the expression of multiple genes, cell-cell adhesion, and cell migration and polarity. This review focuses on the roles of GC signaling in the adhesion, migration, and metastasis of BC cells. We discuss the molecular mechanisms of GC actions that lead to BC metastasis and propose alternative pharmacological uses of GCs for BC treatment.

【 授权许可】

CC BY-NC   
© The Author(s) 2020

【 图 表 】

Figure 1.