Identification of Breast Cancer-Associated Lipids in Scalp Hair

Breast Cancer: Basic and Clinical Research

Original Research

Joseph Haklani¹  Dharmica A.H. Mistry²  Peter W. French³ 

[1] Fermiscan Ltd., Sydney New South Wales, Australia.;School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.;Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia.;SBC Research, Level 12, 97–99 Bathurst Street, Sydney, New South Wales, Australia.;School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.;SBC Research, Level 12, 97–99 Bathurst Street, Sydney, New South Wales, Australia.;

关键词: hair;    breast cancer;    lipids;    phospholipids;    hair;   

DOI  :  10.4137/BCBCR.S9607

来源: Sage Journals

【 摘 要 】

A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date, the molecular mechanisms leading to this alteration are largely unknown. We have determined that the alteration is likely to be due to the presence of one or more breast cancer-associated phospholipids. Further characterization of these lipids could be used to develop a novel, sensitive and specific screening test for breast cancer, based on hair initially, and potentially extendable to other biological samples.

【 授权许可】

CC BY-NC   
© 2012 SAGE Publications.

【 图 表 】

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