Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK—ERK Signaling Pathway

Cell Transplantation

Article

Min Zhang¹  Xueer Wang¹  Li Sun¹  Shixuan Chen¹  Yanan Kong¹  Yinghua Chen¹  Qin Jia¹  Lin Zhang¹  Nuyun Liu²  Lu Zhang³ 

[1] Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China;Elderly Health Services Research Center, Southern Medical University, Guangzhou, China;Elderly Health Services Research Center, Southern Medical University, Guangzhou, China;Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China;

关键词: Activin B;    Skin;    Wound healing;    Bone marrow-derived mesenchymal stem cells (BMSCs);    c-JUN NH -terminal protein kinase (JNK);    Extracellular signal regulated kinase (ERK);   

DOI  :  10.3727/096368913X666999

 received in 2012-03-27, accepted in 2013-04-09,  发布年份 2014

来源: Sage Journals

【 摘 要 】

Bone marrow-derived mesenchymal stem cells (BMSCs) are able to differentiate into various types of skin cells and participate in skin regeneration and repair. Activin signaling can regulate wound healing and reepithelialization. The present study assessed the impact of activin B on BMSC-mediated cutaneous wound healing in rats and explored the possible mechanism involved. We found that CFSE-labeled BMSCs participated in wound healing in vivo, and compared to administration with PBS, activin B, or BMSCs, activin B plus BMSCs significantly promoted wound healing and hair follicle regeneration. Activin B induced actin stress fiber formation and cell migration in BMSCs in vitro. Activation of JNK and ERK, but not p38, was required for activin B-induced actin stress fiber formation and BMSC migration. These results show that activin B may promote BMSC-mediated wound healing by inducing actin stress fiber formation and BMSC migration via the ERK and JNK signal pathways. Combined administration of BMSCs and cytokines may be a promising therapeutic strategy for the management of skin wounds.

【 授权许可】

Unknown   
© 2014 Cognizant Comm. Corp.

【 图 表 】

Figure 4

Figure 3

Figure 2

Figure 4.

Figure 2.

Figure 14.