Pathophysiological Responses of Pinna nobilis Individuals Enlightens the Etiology of Mass Mortality Situation in the Mediterranean Populations

Cells

John A. Theodorou¹  Ioannis A. Giantsis²  Konstantinos Feidantsis³  Basile Michaelidis³  Athanasios Lattos³  Ioannis Georgoulis³  Alexandra Staikou⁴  Dimitrios Karagiannis⁵ 

[1] Department of Animal Production Fisheries & Aquaculture, University of Patras, 26504 Mesolonghi, Greece;Department of Animal Science, Faculty of Agricultural Sciences, University of Western Macedonia, 53100 Florina, Greece;Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;Laboratory of Zoology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;National Reference Laboratory for Mollusc Diseases, Ministry of Rural Development and Food, 54627 Thessaloniki, Greece;

关键词: Pinna nobilis;    mortality;    pathogens;    Haplosporidium pinnae;    Mycobacterium sp.;    Vibrio spp.;   

DOI  :  10.3390/cells10112838

来源: DOAJ

【 摘 要 】

Due to the rapid decrease of Pinna nobilis populations during the previous decades, this bivalve species, endemic in the Mediterranean Sea, is characterized as ‘critically endangered’. In addition to human pressures, various pathogen infections have resulted in extended reduction, even population extinction. While Haplosporidium pinnae is characterized as one of the major causative agents, mass mortalities have also been attributed to Mycobacterium sp. and Vibrio spp. Due to limited knowledge concerning the physiological response of infected P. nobilis specimens against various pathogens, this study’s aim was to investigate to pathophysiological response of P. nobilis individuals, originating from mortality events in the Thermaikos Gulf and Lesvos and Limnos islands (Greece), and their correlation to different potential pathogens detected in the diseased animals. In isolated tissues, several cellular stress indicators of the heat shock and immune response, apoptosis and autophagy, were examined. Despite the complexity and limitations in the study of P. nobilis mortality events, the present investigation demonstrates the cumulative negative effect of co-infection additionally with H. pinnae in comparison to the non-presence of haplosporidian parasite. In addition, impacts of global climate change affecting physiological performance and immune responses result in more vulnerable populations in infectious diseases, a phenomenon which may intensify in the future.

【 授权许可】

Unknown