KIBRA: a new gateway to learning and memory?

Frontiers in Aging Neuroscience

Karoly Nikolich¹  Armin Schneider²  Matthew JHuentelman³  Kerstin Duning⁴ 

[1] Amnestix Incorporated;SYGNIS Bioscience;The Translational Genomics Research Institute (TGen);University Hospital Münster;

关键词: Cognition;    Hippocampus;    Memory;    Alzheimer's disease;    cognitive impairment;    PKC;    GWAS (genome-wide association study);   

DOI  :  10.3389/neuro.24.004.2010

来源: DOAJ

【 摘 要 】

The genetic locus encoding KIBRA, a member of the WWC family of proteins, has recently been shown to be associated with human memory performance through genome-wide single nucleotide polymorphism screening. Gene expression analysis and a variety of functional studies have further indicated that such a role is biologically plausible for KIBRA. Here, we review the existing literature, illustrate connections between the different lines of evidence, and derive models based on KIBRA’s function(s) in the brain that can be further tested experimentally.

【 授权许可】

Unknown