State of the Art Biocompatible Gold Nanoparticles for Cancer Theragnosis

Pharmaceutics

Dong-Wook Han¹  Moon Sung Kang¹  Ki Su Kim²  So Yun Lee² 

[1] Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Korea;Department of Organic Materials Science and Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Korea;

关键词: gold nanoparticle (AuNP);    cancer therapy;    theragnosis;    photothermal treatment (PTT);    photodynamic therapy (PDT);    cancer imaging;   

DOI  :  10.3390/pharmaceutics12080701

来源: DOAJ

【 摘 要 】

Research on cancer theragnosis with gold nanoparticles (AuNPs) has rapidly increased, as AuNPs have many useful characteristics for various biomedical applications, such as biocompatibility, tunable optical properties, enhanced permeability and retention (EPR), localized surface plasmon resonance (LSPR), photothermal properties, and surface enhanced Raman scattering (SERS). AuNPs have been widely utilized in cancer theragnosis, including phototherapy and photoimaging, owing to their enhanced solubility, stability, biofunctionality, cancer targetability, and biocompatibility. In this review, specific characteristics and recent modifications of AuNPs over the past decade are discussed, as well as their application in cancer theragnostics and future perspectives. In the future, AuNP-based cancer theragnosis is expected to facilitate the development of innovative and novel strategies for cancer therapy.

【 授权许可】

Unknown