Chemical Genetics of Acetyl-CoA Carboxylases

Molecules

Xuyu Zu¹  Jing Zhong¹  Dixian Luo¹  Jingjing Tan¹  Qinghai Zhang¹  Ying Wu¹  Jianghua Liu¹  Renxian Cao¹  Gebo Wen¹ 

[1] ¹Institute of Clinical Medicine, the First Affiliated Hospital, University of South China, Hengyang 421001, Hunan, China

关键词: acetyl-CoA carboxylase;    fatty acid biosynthesis;    ACC chemical genetics;    ACC inhibitors;    cancer therapy;   

DOI  :  10.3390/molecules18021704

来源: mdpi

【 摘 要 】

Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers. In mammals, ACCs have both biotin carboxylase (BC) and carboxyltransferase (CT) activity, catalyzing carboxylation of acetyl-CoA to malonyl-CoA. Several classes of small chemicals modulate ACC activity, including cellular metabolites, natural compounds, and chemically synthesized products. This article reviews chemical genetic studies of ACCs and the use of ACCs for targeted therapy of cancers.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.