Lipid Metabolism and HCV Infection

Viruses

Paul Targett-Adams²  Steeve Boulant³  Mark W. Douglas¹ 

[1] Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, PO Box 412, Westmead, NSW 2145, Australia; E-Mail: [e-mail];Pfizer Global Research & Development, Infectious Diseases Group, Sandwich Laboratories, Sandwich, CT13 9NJ, UK; E-Mail: [e-mail];Immune Disease Institute, Harvard Medical School, Department of Microbiology and Molecular Genetics, Boston, MA 02115, USA; E-Mail: [e-mail]

关键词: hepatitis C virus;    HCV;    lipid metabolism;    lipid droplets;    fatty acid biosynthesis;    cholesterol biosynthesis;    VLDL assembly;    RNA replication;    virus assembly;   

DOI  :  10.3390/v2051195

来源: mdpi

【 摘 要 】

Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body. A number of pathologies have been linked to the impact of HCV infection on liver metabolism. However, there is also growing evidence that hepatic metabolic processes contribute to the HCV life cycle. This review summarizes the relationship between lipid metabolism and key stages in the production of infectious HCV.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland