Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells

Cancers

Artur Rebelo¹  Yoshiaki Sunami¹  Jörg Kleeff¹ 

[1] Department of Visceral, Vascular and Endocrine Surgery, Halle University Hospital, Martin-Luther University Halle-Wittenberg, Halle 06120, Germany;

关键词: pancreatic ductal adenocarcinoma;    pancreatic stellate cells;    lipid metabolism;    lipid droplets;    reprogramming in lipid metabolism;   

DOI  :  10.3390/cancers10010003

来源: DOAJ

【 摘 要 】

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells frequently exhibit reprogramming of their metabolic activity. It is increasingly recognized that aberrant de novo lipid synthesis and reprogrammed lipid metabolism are both associated with the development and progression of various cancers, including pancreatic cancer. In this review, the current knowledge about lipid metabolism and lipid droplets in pancreatic cancer is discussed. In the first part, molecular mechanisms of lipid metabolism and roles of enzymes involved in lipid metabolism which are relevant for pancreatic cancer research are presented. Further, preclinical studies and clinical trials with drugs/inhibitors targeting cancer metabolic systems in cancer are summarized. An increase of our knowledge in lipid metabolism in pancreatic cancer cells and in tumor stroma is important for developing novel strategies of future individualized therapies of pancreatic cancer.

【 授权许可】

Unknown