The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives

Frontiers in Oncology

Yang Wu¹  Chun Zhang¹  Jan G. D’Haese¹  Jens Werner²  Alexandr V. Bazhin²  Kuirong Jiang³ 

[1] Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany;German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany;Pancreas Center and Pancreas Institute, Nanjing Medical University, Nanjing, China;

关键词: pancreatic stellate cells;    pancreatic ductal adenocarcinoma;    tumor microenvironment;    stroma-targeting strategy;    tumor therapy;   

DOI  :  10.3389/fonc.2020.621937

来源: DOAJ

【 摘 要 】

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furthermore, the crosstalk among PSCs, pancreatic cancer cells (PCCs) as well as other stroma cells can establish a growth-supportive tumor microenvironment (TME) of PDAC, thereby enhancing tumor growth, metastasis, and chemoresistance via various pathways. Recently, targeting stroma has emerged as a promising strategy for PDAC therapy, and several novel strategies have been proposed. The aim of our study is to give a profound review of the role of PSCs in PDAC progression and recent advances in stroma-targeting strategies.

【 授权许可】

Unknown