Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices

Journal of Lipid Research

R.S. Leal¹ 

[1] Instituto Bento da Rocha Cabral, Lisbon, Portugal;

关键词: fatty acid biosynthesis;    phospholipid biosynthesis;    triglyceride biosynthesis;    rat;    liver slices;    alkali-metal ions;   

DOI  :  

来源: DOAJ

【 摘 要 】

The influence of alkali-metal ions on the incorporation of labeled precursors into phospholipids and triglycerides was studied in rat liver slices. By use of acetate-1-C14 and palmitate-1-C14 as lipid precursors, a comparison was made of the pathway from acetate to phospholipid and the pathway from palmitate to phospholipid. While the rate of incorporation of palmitate-1-C14 into phospholipids and triglyceride fatty acids was virtually independent of the alkali-metal ion present in the medium, the rate of incorporation of acetate-1-C14 into the same compounds was strongly influenced by the alkali-metal ions, the highest incorporations being obtained with potassium and rubidium. Under the same conditions lithium appears to have an inhibitory effect. The effects of the alkali-metal ions on phospholipid and triglyceride synthesis in liver are located on the pathway between acetate and long-chain fatty acids.

【 授权许可】

Unknown