Genomic Variation-Mediating Fluconazole Resistance in Yeast

Biomolecules

Wen-Yao Wang¹  Si-Yuan Qu¹  Cheng-Cheng Liang¹  Ze-Xiong Xie¹  Ying-Jin Yuan¹  Hong-Qing Cai¹  Wei-Hao Lin¹  Hao Liu¹ 

[1] Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

关键词: antifungal resistance;    fluconazole;    yeast;    genomic variations;    aneuploidy;    loss of heterozygosity;   

DOI  :  10.3390/biom12060845

来源: DOAJ

【 摘 要 】

Fungal infections pose a serious and growing threat to public health. These infections can be treated with antifungal drugs by killing hazardous fungi in the body. However, the resistance can develop over time when fungi are exposed to antifungal drugs by generating genomic variations, including mutation, aneuploidy, and loss of heterozygosity. The variations could reduce the binding affinity of a drug to its target or block the pathway through which drugs exert their activity. Here, we review genomic variation-mediating fluconazole resistance in the yeast Candida, with the hope of highlighting the functional consequences of genomic variations for the antifungal resistance.

【 授权许可】

Unknown