Synthesis and Bioactivity of New Phosphorylated R,R’-substituted Sulfoximines

Molecules

关键词: Disubstituted sulfoximines;    phosphoroamidates;    phosphoroamidothionates ̧ inscticidal activity;    toxicity;    Musca domestica;    house fly acetylcholinesterase;   

DOI  :  10.3390/10111369

来源: DOAJ

【 摘 要 】

R,R’-disubstituted sulfoximines were phosphorylated with O,O–diethylchlorophosphate and phosphorothionate to obtain new organophosphorus compounds. Afterpurification they were characterized by GC-MS and 1H-NMR. The toxicity of thesynthesized O,O-diethyl N-(R,R’-disubstituted sulfoximine) phosphoro-amidothionateswas assayed on Musca domestica. It was found that the methyl phenyl derivative was themost toxic compound, followed by the dipropyl and dibutyl derivatives. The dihexylcompound was the less toxic of all the assayed compounds, being one hundred times lesstoxic than a paraoxon standard The anticholinesterasic activity of the correspondingphosphoramidates was assayed on homogenates of house flies’ heads, giving valuessimilar to paraoxon for the methyl phenyl derivative.

【 授权许可】

Unknown