Synthesis and Bioactivity of New Phosphorylated R,R’‑substituted Sulfoximines

Molecules

Monica Bellozas Reinhard¹ 

[1] Departamento de Química – FCEyN – Univ. Nac. La Pampa - Santa Rosa – Pcia.  La Pampa – Argentina – E-mail:

关键词: Disubstituted sulfoximines;    phosphoroamidates;    phosphoroamidothionates;    inscticidal activity;    toxicity;    Musca domestica;    house fly acetylcholinesterase;   

DOI  :  10.3390/10111369

来源: mdpi

【 摘 要 】

R,R’-disubstituted sulfoximines were phosphorylated with O,O–diethylchloro phosphate and phosphorothionate to obtain new organophosphorus compounds. After purification they were characterized by GC-MS and ¹H-NMR. The toxicity of the synthesized O,O-diethyl N-(R,R’-disubstituted sulfoximine) phosphoro-amidothionates was assayed on Musca domestica. It was found that the methyl phenyl derivative was the most toxic compound, followed by the dipropyl and dibutyl derivatives. The dihexyl compound was the less toxic of all the assayed compounds, being one hundred times less toxic than a paraoxon standard The anticholinesterasic activity of the corresponding phosphoramidates was assayed on homogenates of house flies’ heads, giving values similar to paraoxon for the methyl phenyl derivative.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).