Ganoderma lucidum culture supplement ameliorates dyslipidemia and reduces visceral fat accumulation in type 2 diabetic rats

Mycology

Wei-Kang Lin¹  Shun‐Hsien Chang¹  Guo-Jane Tsai¹  Chung-Hsiung Huang¹ 

[1] National Taiwan Ocean University;

关键词: ganoderma lucidum;    hypolipidemic effect;    lipid metabolism;    submerged culture;    type 2 diabetes;    visceral fat accumulation;   

DOI  :  10.1080/21501203.2020.1740409

来源: DOAJ

【 摘 要 】

Diabetic rats were daily fed with a high-cholesterol diet containing 1% or 3% freeze-dried whole submerged G. lucidum culture or its mycelia for 5 weeks. Body weight, adipose tissue weight and plasma triglyceride levels were reduced, while high-density lipoprotein-cholesterol levels were elevated in rats fed with G. lucidum powder supplement diets. Notably, G. lucidum supplements downregulated the activities of hepatic acetyl-CoA carboxylase, fatty acid synthase and lipoprotein lipase, but upregulated the activity of hormone-sensitive lipase in the perirenal adipose tissues. Moreover, G. lucidum supplements increased the faecal triglyceride excretion. Therefore, daily supplementation of submerged G. lucidum culture, especially mycelia, can ameliorate dyslipidemia and reduce visceral fat accumulation in diabetic rats fed with a high-fat diet, which is closely related to the modulation of lipid synthesis, metabolism, and excretion.

【 授权许可】

Unknown