Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats

Revista Brasileira de Farmacognosia

Pankaj G. Jain¹  Savita D. Patil¹  Nitin G. Haswani¹  Manoj V. Girase¹  Sanjay J. Surana¹ 

[1] ,R.C. Patel Institute of Pharmaceutical Education and ResearchMaharashtra,India

关键词: Moringa oleifera;    HMG Co-A reductase;    hypolipidemic effect;    lipid profile;    Moringa oleifera;    HMG Co-A reductase;    hypolipidemic effect;    lipid profile;   

DOI  :  10.1590/S0102-695X2010005000038

来源: SciELO

【 摘 要 】

The leaves of Moringa oleifera Lam., Moringaceae, are used by the Indians in their herbal medicine as a hypolipidemic agent in obese patients. Albino Wistar rats were fed with methanolic extract of M. oleifera (150, 300 and 600 mg/kg, p.o.) and simvastatin (4 mg/kg, p.o.) along with hyperlipidemic diet for 30 days. Moringa oleifera and simvastatin were found to lower the serum cholesterol, triacylglyceride, VLDL, LDL, and atherogenic index, but were found to increase the HDL as compared to the corresponding high fed cholesterol diet group (control). The Moringa oleifera methanolic extract was also investigated for its mechanism of action by estimating HMG CO-A reductase activity. Moringa oleifera was found to increase the excretion of fecal cholesterol. Thus, the study demonstrates that M. oleifera possesses a hypolipidemic effect.

【 授权许可】

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