Direct oxidation of Δ2-isoxazolines synthesis by metal ion-mediated diastereoface-selective 1,3-dipolar cycloaddition with “activated” DMSO

Arabian Journal of Chemistry

关键词: 1,3-Dipolar cycloaddition;    Δ2-Isoxazol-6(6aH)-one;    Δ2-Isoxazole-4,6(5H,6aH)-dione;    Stereoselectivity;    Swern oxidation;   

DOI  :  10.1016/j.arabjc.2012.12.008

来源: DOAJ

【 摘 要 】

A series of 4-hydroxyl-Δ2-isoxazol-6(6aH)-one derivatives was prepared by magnesium ion-mediated diastereoface-selective 1,3-dipolar cycloaddition of aromatic nitrile oxides with pyrrolidinone derivatives. The reaction of 4-hydroxyl-Δ2-isoxazol-6(6aH)-one derivatives with dimethylsulfoxide and oxalyl chloride under Swern conditions led to a Δ2-isoxazole-4,6(5H,6aH)-dione.

【 授权许可】

Unknown