Green Synthesis and Catalysis | |
Catalyst-free and atom-economical 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines: Facile synthesis of isoquinoline-fused spirocycles | |
Tao Liu1  Yang Wang1  Xiaohan Hou1  Xiaoyang Li1  Hao Dong2  Weiwu Ren2  Lesong Li2  Xiaoli Zhang2  | |
[1] Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China;;Molecular Synthesis Center & | |
关键词: Catalyst-free; Atom-economical; 1,3-Dipolar cycloaddition; C,N-cyclic azomethine imine; 5-Alkenyl thiazolone; 2-Arylidenindane-1,3-dione; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
A highly efficient and environmentally benign 1,3-dipolar cycloaddition of C,N - cyclic azomethine imines with 5-alkenyl thiazolones and 2-arylidenindane-1,3-diones is developed for the construction of congested quaternary spiro-carbon centers. All these transformations can be smoothly performed in ethanol at room temperature, providing a catalyst-free and atom-economical access to diversely substituted novel isoquinoline-fused spirocycles in almost quantitative yields with high diastereoselectivities. The promising anti-tumor activity of these structurally novel spirocyclic compounds is reported as well.
【 授权许可】
Unknown