Synthesis and antimicrobial evaluation of 1,4-disubstituted 1,2,3-triazoles with aromatic ester functionality

Arabian Journal of Chemistry

卷:9

Dharmendra Singh¹  C.P. Kaushik²  Krishan Kumar²  S.K. Singh³  Sangita Saini⁴ 

[1] Centre for Research & Development, IPCA Lab Ltd., Kandivali, Mumbai, Maharashtra 400101, India;

[2] Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, India;

[3] Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, India;

[4] Department of Pharmaceutical Sciences, PDM College of Pharmacy, Bahadurgarh, Haryana 124507, India;

关键词: Click chemistry;    1,4-Disubstituted 1,2,3-triazoles;    1,3-Dipolar cycloaddition;    Antibacterial activity;    Antifungal activity;   

DOI  :  10.1016/j.arabjc.2013.09.023

来源: DOAJ

【 摘 要 】

A series of 1,4-disubstituted 1,2,3-triazoles having p-substituted aromatic ester functionality were synthesized via Cu(I) catalysed click reaction between p-substituted benzoic acid prop-2-ynyl esters and aralkyl azides. The synthesized triazoles were characterized by IR, 1H NMR, 13C NMR and mass spectral techniques. These compounds were evaluated for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Candida albicans, Aspergillus niger and Aspergillus flavus by two fold serial dilution method. Some of the synthesized 1,4-disubstituted 1,2,3-triazoles possess comparable or even better antibacterial, antitubercular and antifungal activities than reference drugs against tested bacterial, mycobacterial and fungal strains, respectively.

【 授权许可】

Unknown