“Data characterizing microfabricated human blood vessels created via hydrodynamic focusing”

Data in Brief

Kyle A. DiVito¹  André A. Adams¹  Steven A. Roberts¹  Michael A. Daniele²  Frances S. Ligler³ 

[1] Center for Bio/Molecular Science & Engineering US Naval Research Laboratory, 4555 Overlook Ave. SW, Washington D.C. 20375, United States;Department of Electrical & Computer Engineering North Carolina State University, 890 Oval Dr., Raleigh NC 27695, United States;Joint Department of Biomedical Engineering North Carolina State University and University of North Carolina-Chapel Hill, 911 Oval Dr., Raleigh NC 27695, United States;

关键词: Microfluidics;    GelMA;    Endothelial cell;    Blood vessel;    Microvessel;    Organ-on-chip;   

DOI  :  10.1016/j.dib.2017.07.011

来源: DOAJ

【 摘 要 】

This data article provides further detailed information related to our research article titled “Microfabricated Blood Vessels Undergo Neovascularization” (DiVito et al., 2017) [1], in which we report fabrication of human blood vessels using hydrodynamic focusing (HDF). Hydrodynamic focusing with advection inducing chevrons were used in concert to encase one fluid stream within another, shaping the inner core fluid into ‘bullseye-like” cross-sections that were preserved through click photochemistry producing streams of cellularized hollow 3-dimensional assemblies, such as human blood vessels (Daniele et al., 2015a, 2015b, 2014, 2016; Roberts et al., 2016) [2–6]. Applications for fabricated blood vessels span general tissue engineering to organ-on-chip technologies, with specific utility in in vitro drug delivery and pharmacodynamics studies. Here, we report data regarding the construction of blood vessels including cellular composition and cell positioning within the engineered vascular construct as well as functional aspects of the tissues.

【 授权许可】

Unknown