Sustained delivery of osteogenic growth peptide through injectable photoinitiated composite hydrogel for osteogenesis

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Qingxun Meng¹  Xiaodi Sun¹  Jian Zhang¹  Beibei Liu¹  Jiannan Wu¹ 

[1] Department of Oral Implantology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China;Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China;

关键词: OGP;    GelMA;    HAMA;    bone tissue engineering;    photo-crosslinking;    sustained release;   

DOI  :  10.3389/fbioe.2023.1228250

 received in 2023-05-24, accepted in 2023-07-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

One of the most challenging clinical issues continues to be the effective bone regeneration and rebuilding following bone abnormalities. Although osteogenic growth peptide (OGP) has been proven to be effective in promoting osteoblast activity, its clinical application is constrained by abrupt release and easily degradation. We developed a GelMA/HAMA dual network hydrogel loaded with OGP based on a combination of physical chain entanglement and chemical cross-linking effects to produce an efficient long-term sustained release of OGP. The hydrogel polymers were quickly molded under ultraviolet (UV) light and had the suitable physical characteristics, porosity structure and biocompatibility. Significantly, the GelMA/HAMA-OGP hydrogel could promote cell proliferation, adhesion, increase osteogenic-related gene and protein expression in vitro. In conclusion, the OGP sustained-release system based on GelMA/HAMA dual network hydrogel offers a fresh perspective on bone regeneration therapy.

【 授权许可】

Unknown   
Copyright © 2023 Liu, Wu, Sun, Meng and Zhang.