Usefulness of FDG-PET/CT-Based Radiomics for the Characterization and Genetic Orientation of Pheochromocytomas Before Surgery

Cancers

Karine Renaudin-Autain¹  Eric Mirallié²  Delphine Drui³  Anne-Paule Gimenez-Roqueplo⁴  Christophe Leux⁵  Françoise Kraeber-Bodéré⁶  Catherine Ansquer⁶  Antoine Denis⁶  Thomas Carlier⁶  Frederique Toulgoat⁷ 

[1] Anatomopathology Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France;Digestive and Endocrine Surgery Department (CCDE), Institut des Maladies de l’Appareil Digestif (IMAD), University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France;Endocrinology Department, University Hospital of Nantes, Boulevard Jacques Monod, 44092 Nantes, France;Genetic Department, Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 75015 Paris, France;Medical Information Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France;Nuclear Medicine Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France;Radiology Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France;

关键词: pheochromocytoma;    paraganglioma;    18FDG;    PET/CT;    radiomics;    adrenal gland;   

DOI  :  10.3390/cancers12092424

来源: DOAJ

【 摘 要 】

Purpose: To assess the potential added value of FDG-PET/CT radiomics for the characterization of pheochromocytomas (PHEO) and their genetic orientation prior to surgery and genetic testing. Methods: This retrospective monocentric study, included 49 patients (52 tumors) that underwent both FDG-PET/CT and MIBG scan before surgery. A germline mutation was secondarily identified in 13 patients in one of the genes related to Cluster 1 (n = 4) or Cluster 2 (n = 9). No mutation was identified in 32 patients and 4 did not have genetic testing. Correlation between several PET-based biomarkers, including SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG) and textural features, and biochemical and genetic features were analyzed. Results: Sensitivity of FDG-PET/CT alone was 92%, and 98% when combined to MIBG. The SUVmax was significantly higher for mutated tumors classified in Cluster 1 than in Cluster 2 (p = 0.002) or for tumors with no identified mutations (p = 0.04). MTV and TLG of the tumors with the most intense uptake discriminated mutated Cluster 2 from sporadic tumors, but not from Cluster 1 tumors. Textural features combined with MTV led to better differentiation between sporadic and mutated tumors (p<0.05). Conclusion: FDG-PET/CT is useful for preoperative characterization of PHEO, and when combined with radiomics biomarkers, provides evidences for a genetic predisposition.

【 授权许可】

Unknown