Usefulness of Standardized Uptake Values for Distinguishing Adrenal Glands with Pheochromocytoma from Normal Adrenal Glands by Use of 6-18F-Fluorodopamine PET

Journal of Nuclear Medicine

Henri J.L.M. Timmers¹  Clara C. Chen¹  Jorge A. Carrasquillo¹  Alexander Ling¹  Karen T. Adams¹  W. Marston Linehan¹  Graeme Eisenhofer¹  Karel Pacak¹  Peter A. Pinto¹  Millie Whatley¹ 

关键词: 6-¹⁸F-fluorodopamine;    pheochromocytoma;    paraganglioma;    PET;   

DOI  :  10.2967/jnumed.107.043281

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

6-18F-Fluorodopamine (18F-FDA) PET is a highly sensitive tool for the localization of pheochromocytoma (PHEO). The aim of this study was to establish cutoff values for pathologic and physiologic adrenal gland tracer uptake. Methods: 18F-FDA PET with CT coregistration was performed in 14 patients (10 men and 4 women; age [mean ± SD], 42.9 ± 13.3 y) with unilateral adrenal gland PHEO and in 13 control subjects (5 men and 8 women; age, 51.7 ± 12.5 y) without PHEO. Standardized uptake values (SUVs) were compared between adrenal glands with PHEO and normal left adrenal glands in control subjects. Results: 18F-FDA accumulation was observed in all adrenal glands with PHEO and in 6 of 13 control adrenal glands (P = 0.02). The SUV was higher in adrenal glands with PHEO (mean ± SD, 16.1 ± 6.1) than in 18F-FDA–positive control adrenal glands (7.7 ± 1.4) (P = 0.005). SUV cutoffs for distinguishing between adrenal glands with PHEO and normal adrenal glands were 7.3 (100% sensitivity) and 10.1 (100% specificity). Conclusion: The SUVs of adrenal foci on 18F-FDA PET facilitate the distinction between adrenal glands with PHEO and normal adrenal glands.

【 授权许可】

Unknown