Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study

BMC Cancer

Zhaoze Guo¹  Jingyun Guo¹  Xiaoqi Zeng¹  Changsheng Ye¹  Simin Ruan¹  Jianyu Dong¹  Huining Lian¹  Minfeng Liu¹  Yunjiu Cheng²  Lijun Zhu³  Shanshan Jiang⁴ 

[1] Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University;Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University;Department of Ultrasonography, Nanfang Hospital, Southern Medical University;Institute of Hematological Research, Shaanxi Provincial People’s Hospital;

关键词: Cardiovascular disease;    Risk factors;    Breast cancer;    Cohort;    Atherosclerosis risk in communities;    Incidence;   

DOI  :  10.1186/s12885-022-09604-2

来源: DOAJ

【 摘 要 】

Abstract Background Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is still uncertain. Methods Data from the Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort of middle-aged women, were used to investigate the association of individual and combined cardiovascular risk factors with breast cancer. Cox proportional hazards models were applied to calculate the hazard ratio (HR) and 95% confidence intervals (CI). Results A total of 7501 women were included. During a mean follow-up of 19.7 years, 576 women were diagnosed with breast cancer. White women and premenopausal status were independently associated with increased risk of breast cancer. Of the individual cardiovascular risk factors, only obesity was independently associated with an increased risk of breast cancer (HR 1.29, 95% CI 1.04–1.61). Compared with women without cardiovascular risk factors, women having three or greater, but not those with fewer than three cardiovascular risk factors, had a significantly higher risk of developing breast cancer (HR 1.27, 95% CI 1.06–1.53). Subgroup analyses indicated that women with three or greater cardiovascular risk factors had higher risk of breast cancer among postmenopausal Black women, but not among premenopausal Black and White women. Conclusions Combinations of cardiovascular risk factors are associated with increased risk of breast cancer in middle-aged women, especially in postmenopausal Black women. Joint interventions to modify cardiovascular risk factors could be used to prevent breast cancer in these higher-risk individuals.

【 授权许可】

Unknown